CX-5461
CX5461 is an orally bioavailable small molecule that selectively inhibits RNA polymerase I, suppressing ribosomal RNA synthesis. This activity triggers a DNA damage response and demonstrates antitumor efficacy in preclinical models, including in vivo studies of ovarian cancer.
Product Specifications
CAS Number
1138549-36-6
Product Name Alternative
Inhibitor, inhibit, DNA Synthesis, DNA/RNA Synthesis, DNASynthesis, CX 5461, CX5461, CX-5461, RNASynthesis, RNA Synthesis, Pol I-driven transcription of rRNA
Field of Research
Immunology & Inflammation
Purity
>98%
Form
Powder
Solubility
Soluble in DMSO (up to 10 mg/ml with warming)
Smiles
CN1CCCN (CC1) c1ccc2c (n1) n1c3ccccc3sc1c (C (=O) NCc1cnc (C) cn1) c2=O
Molecular Formula
C27H27N7O2S
Molecular Weight
513.6
Storage Conditions
RT
Notes
For research use only.
Other Product Names
2- (Hexahydro-4-methyl-1H-1,4-diazepin-1-yl) -N-[ (5-methyl-2-pyrazinyl) methyl]-5-oxo-5H-benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide
Available Sizes
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