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ABT-263

Navitoclax (ABT-263) is an orally bioavailable small molecule that potently inhibits Bcl-2, Bcl-xL, and Bcl-w (Ki<1 nM), inducing apoptosis. It is widely used in cancer research, demonstrating antitumor activity in both in vitro cellular assays and in vivo xenograft models for studying programmed cell death mechanisms.

Product Specifications

CAS Number

923564-51-6

Product Name Alternative

Navitoclax

Field of Research

Cell Biology, Neuroscience, Stem Cell & Developmental Biology

Purity

>98%

Bioactivity

Bcl-2 family inhibitor, Senolytic agent

Form

Powder

Solubility

Soluble in DMSO (up to 25 mg/ml)

Smiles

C (C1=C (CCC (C) (C) C1) C2=CC=C (Cl) C=C2) N3CCN (CC3) C4=CC=C (C (NS (=O) (=O) C5=CC (S (C (F) (F) F) (=O) =O) =C (N[C@H] (CCN6CCOCC6) CSC7=CC=CC=C7) C=C5) =O) C=C4

Molecular Formula

C47H55ClF3N5O6S3

Molecular Weight

974.6

Storage Conditions

-20°C

Notes

For research use only.

Other Product Names

4-[4-[[2- (4-chlorophenyl) -5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[ (1R) - 3- (4-morpholinyl) -1-[ (phenylthio) methyl]propyl]amino]-3-[ (trifluoromethyl) sulfonyl]-phenyl]sulfonyl]-benzamide

Available Sizes

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