AGI-5198
AGI-5198 is a potent and selective small molecule inhibitor targeting the neomorphic activity of mutant IDH1 enzymes, specifically the R132H and R132C variants, with IC50 values of 70 nM and 160 nM, respectively. It is a valuable research tool for investigating the role of oncometabolite 2-HG in cancers like glioma and AML, both in cellular assays and in vivo models.
Product Specifications
CAS Number
1355326-35-0
Product Name Alternative
Field of Research
Metabolism Research
Purity
>98%
Bioactivity
R132 mutant isocitrate dehydrogenase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 5 mg/ml)
Smiles
Cc1nccn1CC (=O) N (C (C (=O) NC1CCCCC1) c1ccccc1C) c1cccc (F) c1
Molecular Formula
C27H31FN4O2
Molecular Weight
462.56
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
N-[2- (Cyclohexylamino) -1- (2-methylphenyl) -2-oxoethyl]-N- (3-fluorophenyl) -2-methyl-1H-imidazole-1-acetamide
Available Sizes
Frequently Asked Questions
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