Veliparib 2HCl (ABT-888)
Veliparib dihydrochloride is a potent and selective PARP1/2 inhibitor with Ki values of 5.2 nM and 2.9 nM, respectively, while showing no activity against SIRT2. This small molecule is widely used in cancer research, particularly in studying synthetic lethality and chemo/radiosensitization in both cellular and animal models.
Product Specifications
CAS Number
912445-05-7
Product Name Alternative
ABT-888
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology
Purity
>98%
Bioactivity
PARP 1&2 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 30 mg/ml) or in Water (up to 40 mg/ml) .
Smiles
Cl.Cl.C[C@@]1 (CCCN1) c1nc2c (cccc2[nH]1) C (N) =O
Molecular Formula
C13H16N4O • 2HCl
Molecular Weight
317.2
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
2-[ (2R) -2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide, dihydrochloride
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