Venetoclax
Venetoclax (ABT-199) is a highly potent and selective oral Bcl-2 inhibitor (Ki<0.01 nM) with significantly lower affinity for Bcl-xL. It induces apoptosis and autophagy, making it a key tool for cancer research in both in vitro and in vivo models, particularly for studying hematological malignancies.
Product Specifications
CAS Number
1257044-40-8
Product Name Alternative
Venetoclax, Inhibitor, GDC0199, GDC-0199, GDC 0199, inhibit, orally, ABT199, ABT-199, ABT 199, Autophagy, Bcl-2 Family, Bcl-2, bioavailable
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
98.00% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:10 mg/mL (11.51 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:257.5 mg/mL (296.51 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
O=C (C1=CC=C (N2CCN (CC2) CC3=C (CC (C) (CC3) C) C4=CC=C (Cl) C=C4) C=C1OC5=CC6=C (NC=C6) N=C5) NS (=O) (C7=CC=C (C ([N+] ([O-]) =O) =C7) NCC8CCOCC8) =O
Molecular Formula
C45H50ClN7O7S
Molecular Weight
868.44
Storage Conditions
-20°C
Notes
For research use only.
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