PF-4136309
PF-4136309 (INCB8761) is a potent, selective, and orally active antagonist of the CCR2 chemokine receptor. It is a valuable research tool for investigating CCR2-mediated pathways in inflammatory and metabolic diseases, as demonstrated in both cellular assays and animal models.
Product Specifications
CAS Number
1341224-83-6
Product Name Alternative
INCB8761
Field of Research
Immunology & Inflammation
Purity
>98%
Bioactivity
CCR2 antagonist
Form
Powder
Solubility
Soluble in DMSO (up to at least 25 mg/ml)
Smiles
[H][C@@]1 (CC[C@] (O) (CC1) c1ccc (cn1) -c1ncccn1) N[C@H]1CCN (C1) C (=O) CNC (=O) c1cccc (c1) C (F) (F) F
Molecular Formula
C29H31F3N6O3
Molecular Weight
568.60
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
N-[2-[ (3S) -3-[[4-Hydroxy-4- (5-pyrimidin-2-ylpyridin-2-yl) cyclohexyl]amino]pyrrolidin-1-yl]-2-oxoethyl]-3- (trifluoromethyl) benzamide
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