Merestinib
Merestinib (LY2801653) is a potent and selective c-Met inhibitor (Ki: 2 nM) that blocks phosphorylation and downstream signaling, inducing apoptosis in c-Met-dysregulated tumors. It has demonstrated antitumor activity in both in vitro cellular assays and in vivo xenograft models across various cancer research fields, including hepatocellular carcinoma and non-small cell lung cancer.
Product Specifications
CAS Number
1206799-15-6
Product Name Alternative
Inhibit, LY2801653, LY-2801653, LY 2801653, Met, Inhibitor, HGFR, Merestinib, FLT3, DDR, Fms like tyrosine kinase 3, DiscoidinDomainReceptor, Discoidin Domain Receptor (DDR), Discoidin Domain Receptor, DiscoidinDomainReceptor (DDR), cMet, c-Met, cMet/HGFR, c-Met/HGFR, Cluster of differentiation antigen 135, CD135, ROS, ROS Kinase, ROSKinase
Field of Research
Cardiovascular Research, Immunology & Inflammation, Signal Transduction
Purity
95.00% (May vary between batches)
Solubility
DMSO:16 mg/mL (28.96 mM) ; Ethanol:93 mg/mL (168.32 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.97 mM)
Smiles
O (C1=C (C=C2C (=C1) C=NN2C) C=3C=NNC3) C4=C (F) C=C (NC (=O) C=5C (=O) N (C (C) =CC5) C6=CC=C (F) C=C6) C=C4
Molecular Formula
C30H22F2N6O3
Molecular Weight
552.53
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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