RO 46-8443
RO 46-8443 is a selective, non-peptide antagonist of the endothelin ETB receptor, exhibiting up to 2000-fold selectivity in both binding and functional assays. This tool compound is used in vitro and in vivo to investigate ETB receptor function in cardiovascular and renal research.
Product Specifications
CAS Number
175556-12-4
Product Name Alternative
Hypertensive rats, ET-B, ETB, EndothelinReceptor, Endothelin Receptor, Inhibitor, normotensive, non-peptide, inhibit, RO 46 8443, RO 468443, Ro 46-8443, RO 46-8443, selective
Field of Research
Pharmacology & Drug Discovery
Purity
98.50% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.28 mM) ; DMSO:55 mg/mL (90.21 mM)
Smiles
COc1ccc (cc1) -c1nc (NS (=O) (=O) c2ccc (cc2) C (C) (C) C) c (Oc2ccccc2OC) c (OC[C@H] (O) CO) n1
Molecular Formula
C31H35N3O8S
Molecular Weight
609.69
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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