Ro 67-7476
Ro 67-7476 is a potent and selective positive allosteric modulator of rat mGluR1a (EC50 = 60.1 nM), enhancing glutamate-induced calcium release. It also acts as a P-ERK1/2 agonist, independently stimulating ERK1/2 phosphorylation (EC50 = 163.3 nM) . This compound is a valuable research tool for studying mGluR1 signaling in neurological disease models, both in vitro and in vivo.
Product Specifications
CAS Number
298690-60-5
Product Name Alternative
CAMP accumulation, Inhibitor, excitatory postsynaptic potentials, Metabotropic glutamate receptors, mGluR, mGluR1, neuronal culture, inhibit, traumatic injury, Ro 67 7476, Ro 677476, Ro 67-7476
Field of Research
Neuroscience
Purity
99.48% (May vary between batches)
Solubility
DMSO:50 mg/mL (156.55 mM)
Smiles
Cc1ccc (cc1) S (=O) (=O) N1CCC[C@H]1c1ccc (F) cc1
Molecular Formula
C17H18FNO2S
Molecular Weight
319.39
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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