C29
C29 is a selective small molecule inhibitor of Toll-like receptor 2 (TLR2) heterodimer signaling. It potently blocks both TLR2/1 and TLR2/6 pathways induced by synthetic and bacterial ligands in human cell lines (HEK-TLR2, THP-1), but specifically inhibits TLR2/1 signaling in murine macrophages. This tool compound is useful for in vitro research dissecting TLR2-mediated immune responses in infection, inflammation, and autoimmunity.
Product Specifications
CAS Number
363600-92-4
Product Name Alternative
Toll-like Receptor (TLR), Toll-like, TLR, TLR2/1, TLR2, TLR2/6, Inhibitor, inhibit, hTLR2/1, hTLR2/6, C 29, C29, C-29
Field of Research
Immunology & Inflammation
Purity
96.34% (May vary between batches)
Solubility
DMSO:125 mg/mL (438.15 mM) ; H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.01 mM)
Smiles
COc1cccc (\C=N\c2cccc (C (O) =O) c2C) c1O
Molecular Formula
C16H15NO4
Molecular Weight
285.29
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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