Nazartinib
Nazartinib (EGF816) is an irreversible, mutant-selective EGFR inhibitor. It potently and selectively targets common activating mutations (L858R, ex19del) and the T790M resistance mutation, showing significant selectivity over wild-type EGFR in biochemical and cellular assays. Its research applications include in vitro mechanistic studies and in vivo models of non-small cell lung cancer (NSCLC) .
Product Specifications
CAS Number
1508250-71-2
Product Name Alternative
Field of Research
Cardiovascular Research, Signal Transduction
Purity
≥95% (May vary between batches)
Solubility
Ethanol:92 mg/mL (185.85 mM) ; DMSO:92 mg/mL (185.85 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CN (C) C\C=C\C (=O) N1CCCC[C@H] (C1) n1c (NC (=O) c2ccnc (C) c2) nc2cccc (Cl) c12
Molecular Formula
C26H31ClN6O2
Molecular Weight
495.02
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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