GSK180736A
GSK180736A is a potent and selective GRK2 inhibitor (IC50 = 0.77 μM) with over 100-fold selectivity for GRK2 over other GRK isoforms. It also effectively inhibits ROCK1 (IC50 = 100 nM) and shows weaker activity against PKA. This compound is a valuable research tool for investigating GPCR signaling and Rho-ROCK pathways in cardiovascular and fibrotic disease models.
Product Specifications
CAS Number
817194-38-0
Product Name Alternative
ROK, ROCK, Rho-kinase, Rho-associated kinase, Rho-associated protein kinase, PKA, Inhibitor, inhibit, GSK180736, GSK-180736, GSK180736A, GSK-180736A, GSK 180736, GRK1, GRK2, GRK5
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.16% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.47 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:60 mg/mL (164.22 mM) ; Ethanol:3 mg/mL (8.21 mM)
Smiles
CC1=C (C (NC (=O) N1) c1ccc (F) cc1) C (=O) Nc1ccc2[nH]ncc2c1
Molecular Formula
C19H16FN5O2
Molecular Weight
365.36
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
E3232h 96 Tests
ELISA Kit For Recombining binding protein suppressor of hairless
Sign In for Pricing
View Details