Setipiprant
Setipiprant is a potent and selective CRTH2 antagonist (IC50: 6.0 nM) that blocks the PGD2-mediated chemotaxis and activation of Th2 cells, eosinophils, and basophils. It is widely used in preclinical research to investigate allergic asthma and other inflammatory diseases, with applications in both in vitro cellular assays and in vivo animal models.
Product Specifications
CAS Number
866460-33-5
Product Name Alternative
CRTh2, dog, asthma, cAMP, calcium liberation, ACT 129968, ACT129968, ACT-129968, KYTH 105, KYTH105, KYTH-105, inhibit, oral, Inhibitor, HEK-293, rhinitis, ProstaglandinReceptor, Prostaglandin Receptor, Setipiprant, selective, rat
Field of Research
Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery
Purity
99.16% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.97 mM) ; DMSO:45 mg/mL (111.82 mM)
Smiles
C (C (O) =O) N1C2=C (C=3C1=CC=C (F) C3) CN (C (=O) C=4C5=C (C=CC4) C=CC=C5) CC2
Molecular Formula
C24H19FN2O3
Molecular Weight
402.42
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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