Senicapoc
Senicapoc (ICA-17043) is a potent Gardos channel inhibitor with low nanomolar IC50 values, effectively preventing calcium-induced potassium efflux and red blood cell dehydration in vitro. It has demonstrated therapeutic potential in preclinical models for sickle cell disease by ameliorating RBC pathology.
Product Specifications
CAS Number
289656-45-7
Product Name Alternative
KcsA, inhibit, Inhibitor, Gardos channel, ICA-17043, ICA17043, ICA 17043, PotassiumChannel, Potassium Channel, Senicapoc
Field of Research
Pharmacology & Drug Discovery
Purity
95.70% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.19 mM) ; DMSO:50 mg/mL (154.64 mM)
Smiles
NC (=O) C (c1ccccc1) (c1ccc (F) cc1) c1ccc (F) cc1
Molecular Formula
C20H15F2NO
Molecular Weight
323.34
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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