Y16
Y16 is a potent and specific inhibitor of the Rho GEF LARG, binding with a Kd of 76 nM to block the LARG-RhoA interaction. This inhibition prevents RhoA activation and its downstream signaling pathways. Its utility, demonstrated in vitro, makes it a valuable chemical probe for researching RhoA-mediated cellular processes such as cytoskeletal dynamics and cancer cell invasion.
Product Specifications
CAS Number
429653-73-6
Product Name Alternative
Inhibit, Inhibitor, Ras, Y16, Y-16, Y 16, Rho GEFs
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.26% (May vary between batches)
Solubility
DMSO:10 mg/mL (26.01 mM) ;10% DMSO+90% Corn Oil:1 mg/mL (2.6 mM)
Smiles
Cc1cccc (COc2cccc (\C=C3/C (=O) NN (C3=O) c3ccccc3) c2) c1
Molecular Formula
C24H20N2O3
Molecular Weight
384.43
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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