SU-4312
SU-4312 (DMBI) is a selective VEGFR and PDGFR tyrosine kinase inhibitor (IC50 = 0.8 and 19.4 μM, respectively) . It has also been shown to protect against MPP+-induced neurotoxicity in research models by directly inhibiting neuronal nitric oxide synthase (nNOS), indicating utility in neuroprotection and angiogenesis studies.
Product Specifications
CAS Number
5812-07-7
Product Name Alternative
Inhibit, Inhibitor, NSC 86429, NSC86429, NSC-86429, PDGFR, Platelet-derived growth factor receptor, SU 4312, SU4312, SU-4312, Vascular endothelial growth factor receptor, VEGFR
Field of Research
Cardiovascular Research, Cell Biology, Neuroscience
Purity
>98%
Bioactivity
VEGFR / PDGFR kinase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml) .
Smiles
CN (C) c1ccc (\C=C2/C (=O) Nc3ccccc23) cc1
Molecular Formula
C17H16N2O
Molecular Weight
264.3
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
3- (4-Dimethylaminobenzylidene) -1,3-dihydroindol-2-one
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