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Macozinone

Macozinone (PBTZ169) is a potent small molecule inhibitor of the Mycobacterium tuberculosis enzyme DprE1, demonstrating superior inhibitory activity compared to BTZ043. It serves as a key research tool for investigating tuberculosis drug mechanisms and has shown efficacy in both in vitro and in vivo preclinical studies.

Product Specifications

CAS Number

1377239-83-2

Product Name Alternative

Tuberculosis, antituberculosis, Bacterial, bactericidal, benzothiazinone, covalent, DprE1, inhibit, Inhibitor, Macozinone, PBTZ 169, PBTZ169, PBTZ-169

Field of Research

Infectious Disease & Virology

Purity

99.50% (May vary between batches)

Solubility

DMSO:4.57 mg/mL (10.01 mM)

Smiles

[O-][N+] (=O) c1cc (cc2c1sc (nc2=O) N1CCN (CC2CCCCC2) CC1) C (F) (F) F

Molecular Formula

C20H23F3N4O3S

Molecular Weight

456.48

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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