Dolutegravir
Dolutegravir is a potent two-metal-binding HIV-1 integrase inhibitor with an IC50 of 2.7 nM. It demonstrates intermediate antiviral activity against key raltegravir-resistant mutants, including Y143R, Q148K, N155H, and G140S/Q148H. This small molecule is widely used in antiretroviral research for both in vitro mechanistic studies and in vivo efficacy models.
Product Specifications
CAS Number
1051375-16-6
Product Name Alternative
Dolutegravir, inhibit, Inhibitor, Human immunodeficiency virus, HIVProtease, HIV, HIV integrase, HIV Integrase, HIV Protease, GSK 1349572, GSK1349572, GSK-1349572, S/GSK 1349572, S/GSK1349572, S/GSK-1349572
Field of Research
Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry
Purity
98.97% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.87 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:84 mg/mL (200.3 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
C[C@@H]1CCO[C@H]2Cn3cc (C (=O) NCc4ccc (F) cc4F) c (=O) c (O) c3C (=O) N12
Molecular Formula
C20H19F2N3O5
Molecular Weight
419.38
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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