Combretastatin A4
Combretastatin A4 (CA4) is a potent small molecule that binds to β-tubulin with high affinity (Kd: 0.4 μM), functioning as a microtubule-destabilizing agent. It is widely used in cancer research for its anti-angiogenic and vascular-disrupting properties, applicable in both in vitro cytotoxicity assays and in vivo tumor model studies.
Product Specifications
CAS Number
117048-59-6
Product Name Alternative
CA 4, CA4, CA-4, Combretastatin A 4, Combretastatin A4, Combretastatin A-4, CRC 87-09, Microtubule Associated, Microtubule/Tubulin, MicrotubuleAssociated, inhibit, Inhibitor, Tubulin β
Field of Research
Signal Transduction
Purity
98.21% (May vary between batches)
Solubility
DMSO:250 mg/mL (790.26 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (7.9 mM) ; Ethanol:31.6 mg/mL (99.89 mM)
Smiles
O (C) C1=C (OC) C=C (/C=C\C2=CC (O) =C (OC) C=C2) C=C1OC
Molecular Formula
C18H20O5
Molecular Weight
316.35
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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