Irinotecan
Irinotecan (CPT-11) is a camptothecin-derived topoisomerase I inhibitor used in cancer research. It induces lethal double-strand DNA breaks by stabilizing the Topo I-DNA complex. This mechanism underpins its application in studying colorectal and other cancers in both in vitro and in vivo experimental models.
Product Specifications
CAS Number
97682-44-5
Product Name Alternative
Inhibit, Inhibitor, Irinotecan, CPT 11, CPT11, CPT-11, Autophagy, (+) -Irinotecan, Topoisomerase, Topo I, Topotecin
Field of Research
Cell Biology, Molecular Biology, Pharmacology & Drug Discovery
Purity
98.00% (May vary between batches)
Solubility
DMSO:11 mg/mL (18.75 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.2 mg/mL (5.45 mM)
Smiles
CCc1c2Cn3c (cc4c (COC (=O) [C@]4 (O) CC) c3=O) -c2nc2ccc (OC (=O) N3CCC (CC3) N3CCCCC3) cc12
Molecular Formula
C33H38N4O6
Molecular Weight
586.68
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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