XL888
XL888 is a potent, orally bioavailable ATP-competitive inhibitor of Hsp90 (IC50 = 24 nM) . By disrupting this chaperone's function, it induces the degradation of client proteins, leading to cell cycle arrest and apoptosis. It has demonstrated in vivo efficacy, including tumor regression in mouse xenograft models of gastric carcinoma and melanoma.
Product Specifications
CAS Number
1149705-71-4
Product Name Alternative
HSP90, HSP, Heat shock proteins, Inhibitor, inhibit, XL888, XL-888, XL 888
Field of Research
Cell Biology, Metabolism Research, Signal Transduction
Purity
98.10% (May vary between batches)
Solubility
DMSO:55 mg/mL (109.2 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.99 mM)
Smiles
CC[C@@H] (C) Nc1cc (C (=O) N[C@@H]2C[C@@H]3CC[C@H] (C2) N3c2ccc (cn2) C (=O) C2CC2) c (C) cc1C (N) =O
Molecular Formula
C29H37N5O3
Molecular Weight
503.64
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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