Avagacestat
Avagacestat (BMS-708163) is an orally active, potent, and selective γ-secretase inhibitor, showing preferential inhibition of Aβ40/Aβ42 production over Notch signaling. It has been utilized in preclinical and clinical phase 2 research for investigating Alzheimer's disease pathogenesis and potential therapeutic strategies.
Product Specifications
CAS Number
1146699-66-2
Product Name Alternative
Avagacestat, BMS 708163, BMS708163, BMS-708163, Gamma secretase, Gammasecretase, inhibit, Notch, Inhibitor, γ secretase (Aβ40), γ secretase (Aβ42), γ-secretase
Field of Research
Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology
Purity
98.87% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+90% Corn Oil:4 mg/mL (7.68 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:96 mg/mL (184.3 mM)
Smiles
NC (=O) [C@@H] (CCC (F) (F) F) N (Cc1ccc (cc1F) -c1ncon1) S (=O) (=O) c1ccc (Cl) cc1
Molecular Formula
C20H17ClF4N4O4S
Molecular Weight
520.89
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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