What is the catalog number for Ipatasertib?

The catalog number for Ipatasertib is orb1300935.

What sizes are available for Ipatasertib?

Ipatasertib is available in the following size(s): 5 mg, 25 mg.

How many pack sizes does Ipatasertib come in?

Ipatasertib is available in 2 different pack sizes.

Is Ipatasertib in stock?

Ipatasertib is currently made to order / not held in immediate stock. Contact us for lead time.

Ipatasertib

Ipatasertib (GDC-0068) is a potent, ATP-competitive pan-Akt inhibitor with low nanomolar IC50 values against Akt1, Akt2, and Akt3. It induces p53-independent apoptosis by inhibiting Akt to activate FoxO3a and NF-κB, which co-transcribe PUMA, leading to Bax-mediated mitochondrial apoptosis. This mechanism has been investigated in vitro and in vivo for cancer research, particularly in tumors with PTEN deficiency or Akt hyperactivation.

Product Specifications

CAS Number

1001264-89-6

Product Name Alternative

GDC-0068; RG7440

Field of Research

Cell Biology

Purity

>98%

Bioactivity

Pan-Akt inhibitor

Form

Powder

Solubility

Soluble in DMSO (up to 25 mg/ml) or ethanol (up to 20 mg/ml)

Smiles

C[C@H]1C2=C (N=CN=C2[C@H] (O) C1) N3CCN (C ([C@H] (CNC (C) C) C4=CC=C (Cl) C=C4) =O) CC3

Molecular Formula

C24H32ClN5O42

Molecular Weight

458.0

Storage Conditions

-20°C

Notes

For research use only.

Other Product Names

(2S) -2- (4-Chlorophenyl) -1-[4-[ (5R,7R) -7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3- (propan-2-yla, ino) propan-1-one