Idasanutlin
Idasanutlin (RG-7388) is a potent and selective MDM2-p53 interaction inhibitor with an IC50 of 6 nM. It is widely used in cancer research to reactivate p53 function, demonstrating efficacy in both in vitro cell-based assays and in vivo tumor models.
Product Specifications
CAS Number
1229705-06-9
Product Name Alternative
E3Enzyme, E3 ligating enzyme, E2Enzyme, E3 Enzyme, E2 Enzyme, E2 conjugating enzyme, E1 activating enzyme, E1 Enzyme, E1/E2/E3 Enzyme, E1Enzyme, inhibit, Idasanutlin, Inhibitor, Mdm2, MDM-2/p53, Ubiquitin ligase, Ubiquitin conjugating enzyme, Ubiquitin activating enzyme, Ro 5503781, RG7388, RG-7388, RG 7388
Field of Research
Cell Biology, Protein Biochemistry
Purity
98.85% (May vary between batches)
Solubility
20% Cremophor EL:5 mg/mL (8.11 mM) ; Ethanol:8 mg/mL (12.98 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:65 mg/mL (105.44 mM)
Smiles
COc1cc (ccc1NC (=O) C1NC (CC (C) (C) C) C (C#N) (C1c1cccc (Cl) c1F) c1ccc (Cl) cc1F) C (O) =O
Molecular Formula
C31H29Cl2F2N3O4
Molecular Weight
616.48
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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