PP2
PP2 is a potent and selective inhibitor of the Src-family kinases Lck and Fyn, with IC50 values of 4 nM and 5 nM, respectively. It exhibits over 100-fold selectivity against EGFR and is inactive against ZAP-70, PKA, and JAK2. This compound is widely used in vitro to investigate T-cell receptor signaling and immune cell activation pathways.
Product Specifications
CAS Number
172889-27-9
Product Name Alternative
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
Src family kinase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml with warming) .
Smiles
NC1=C2C (=NN (C (C) (C) C) C2=NC=N1) C3=CC=C (Cl) C=C3
Molecular Formula
C15H16ClN5
Molecular Weight
301.78
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
3- (4-Chlorophenyl) -1- (1,1-dimethylethyl) -1H-pyrazolo[3,4-d]pyrimidin-4-amine
Available Sizes
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