R428

Bemcentinib (R428) is a potent and selective Axl kinase inhibitor with an IC50 of 14 nM. It has been studied in non-small cell lung cancer (NSCLC) research, demonstrating activity in both in vitro cellular assays and in vivo tumor models.

Product Specifications

CAS Number

1037624-75-1

Product Name Alternative

Bemcentinib; BGB324

Field of Research

Immunology & Inflammation

Purity

>98%

Bioactivity

Potent and selective AXL inhibitor

Form

Powder

Solubility

Soluble in DMSO (up to at least 25 mg/ml)

Smiles

Nc1nc (Nc2ccc3CC[C@@H] (CCc3c2) N2CCCC2) nn1-c1cc2CCCc3ccccc3-c2nn1

Molecular Formula

C30H34N8

Molecular Weight

506.64

Storage Conditions

-20°C

Notes

For research use only.

Other Product Names

1- (3,4-Diazatricyclo[9.4.0.02,7]pentadeca-1 (15),2,4,6,11,13-hexaen-5-yl) -3-N-[ (7S) -7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine