Tipifarnib
Tipifarnib (IND 58359) is a quinolinone-based farnesyltransferase inhibitor with antineoplastic properties. By blocking Ras protein farnesylation, it disrupts oncogenic signaling, leading to inhibited cell proliferation, induced apoptosis, and suppressed angiogenesis in preclinical cancer research, including studies on hematologic malignancies and solid tumors.
Product Specifications
CAS Number
192185-72-1
Product Name Alternative
IND58359, IND-58359, IND 58359, inhibit, Inhibitor, Ftase, Farnesyl Transferase, Zarnestra, Tipifarnib, R-115777, R115777, R 115777
Field of Research
Metabolism Research
Purity
97.10% (May vary between batches)
Solubility
Ethanol:9.8 mg/mL (20.02 mM) ; DMSO:48.9 mg/mL (99.92 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.09 mM)
Smiles
Cn1cncc1[C@@] (N) (c1ccc (Cl) cc1) c1ccc2n (C) c (=O) cc (-c3cccc (Cl) c3) c2c1
Molecular Formula
C27H22Cl2N4O
Molecular Weight
489.4
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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