RO4929097
RO4929097 (RG-4733) is a potent γ-secretase inhibitor with an IC50 of 4 nM, effectively blocking the cellular production of Aβ40 and Notch cleavage with EC50 values of 14 nM and 5 nM, respectively. This compound is a valuable research tool for investigating Alzheimer's disease pathology and Notch signaling in both cellular and animal models.
Product Specifications
CAS Number
847925-91-1
Product Name Alternative
Field of Research
Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology
Purity
97.68% (May vary between batches)
Solubility
H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.03 mM) ; Ethanol:13 mg/mL (27.69 mM) ; DMSO:122.5 mg/mL (260.97 mM)
Smiles
CC (C) (C (=O) NCC (F) (F) C (F) (F) F) C (=O) N[C@H]1c2ccccc2-c2ccccc2NC1=O
Molecular Formula
C22H20F5N3O3
Molecular Weight
469.4
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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