TW-37
TW-37 is a small molecule, nonpeptide inhibitor targeting the anti-apoptotic proteins Bcl-2, Bcl-xL, and Mcl-1 with Kis of 0.29, 1.11, and 0.26 μM, respectively. It is widely used in cancer research to study apoptosis mechanisms and has demonstrated pro-apoptotic activity in various in vitro cellular assays and in vivo xenograft models.
Product Specifications
CAS Number
877877-35-5
Product Name Alternative
Bcl-2, Bcl-2 Family, Bcl-xL, Mcl-1, Inhibitor, inhibit, TW 37, TW37, TW-37
Field of Research
Cell Biology
Purity
≥95% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.49 mM) ; DMSO:57.4 mg/mL (100.05 mM)
Smiles
CC (C) c1ccccc1Cc1cc (C (=O) Nc2ccc (cc2) S (=O) (=O) c2ccccc2C (C) (C) C) c (O) c (O) c1O
Molecular Formula
C33H35NO6S
Molecular Weight
573.7
Storage Conditions
-20°C
Notes
For research use only.
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