GSK-690693
GSK-690693 is a potent, pan-Akt inhibitor with IC50 values of 2, 13, and 9 nM for Akt1, Akt2, and Akt3, respectively. It also inhibits related AGC kinases like PKA and PKC. This compound has been used in preclinical research to study PI3K/Akt signaling in cancer models, both in vitro and in vivo.
Product Specifications
CAS Number
937174-76-0
Product Name Alternative
Protein kinase B, PKB, PKCθ, PKCη, Serine Protease, SerineProtease, PrkX, inhibit, GSK 690693, GSK690693, GSK-690693, Inhibitor, AMP-activated protein kinase, AMPK, Autophagy, Akt, Akt1, Akt3
Field of Research
Cell Biology, Epigenetics & Chromatin, Protein Biochemistry, Signal Transduction
Purity
97.54% (May vary between batches)
Solubility
DMF:soluble; DMSO:18.33 mg/mL (43.08 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.7 mM)
Smiles
CCn1c (nc2c (ncc (OC[C@H]3CCCNC3) c12) C#CC (C) (C) O) -c1nonc1N
Molecular Formula
C21H27N7O3
Molecular Weight
425.48
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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