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Tariquidar

Tariquidar (XR9576) is a potent, non-competitive P-glycoprotein inhibitor with a Kd of 5.1 nM. It is widely used in vitro to reverse multidrug resistance in cancer cell lines and has been applied in vivo to investigate pharmacokinetic enhancement of chemotherapeutic agents.

Product Specifications

CAS Number

206873-63-4

Product Name Alternative

Tariquidar, Pgp, P-gp, P-gp (P-glycoprotein), P-glycoprotein, XR9576, XR-9576, XR 9576, Cluster of differentiation 243, CD243, ABCB1, Multidrug resistance protein 1, inhibit, Inhibitor, MDR1

Field of Research

Neuroscience, Pharmacology & Drug Discovery

Purity

98.07% (May vary between batches)

Solubility

DMSO:49.5 mg/mL (76.54 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.55 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble)

Smiles

COc1cc2CCN (CCc3ccc (NC (=O) c4cc (OC) c (OC) cc4NC (=O) c4cnc5ccccc5c4) cc3) Cc2cc1OC

Molecular Formula

C38H38N4O6

Molecular Weight

646.73

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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