17-AAG
Tanespimycin (KOS 953) is a potent and selective Hsp90 inhibitor (IC50=5 nM) that reduces intracellular levels and activity of STK38/NDR1 while also downregulating its gene expression. This compound has been utilized in both in vitro and in vivo research models to study oncogenic signaling pathways, protein degradation, and cancer therapeutics.
Product Specifications
CAS Number
75747-14-7
Product Name Alternative
Tanespimycin
Field of Research
Cardiovascular Research, Cell Biology, Protein Biochemistry
Purity
>99%
Bioactivity
HSP90 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 5 mg/ml) .
Smiles
CO[C@H]1C[C@H] (C) CC2=C (NCC=C) C (=O) C=C (NC (=O) \C (C) =C\C=C/[C@H] (OC) [C@@H] (OC (N) =O) \C (C) =C\[C@H] (C) [C@H]1O) C2=O
Molecular Formula
C31H43N3O8
Molecular Weight
585.7
Storage Conditions
RT
Notes
For research use only.
Other Product Names
17- (Allylamino) -17-desmethoxygeldanamycin
Available Sizes
Frequently Asked Questions
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