WZ4003
WZ4003 is a potent and selective NUAK kinase inhibitor, exhibiting IC50 values of 20 nM for NUAK1 and 100 nM for NUAK2 with minimal off-target activity against 139 other kinases. This tool compound is widely used in vitro and in vivo to investigate the roles of NUAK1/2 in cancer biology, cell metabolism, and autophagy.
Product Specifications
CAS Number
1214265-58-3
Product Name Alternative
NUAK1, NUAK2, inhibit, Inhibitor, AMPK, AMP-activated protein kinase, WZ 4003, WZ4003, WZ-4003
Field of Research
Epigenetics & Chromatin, Signal Transduction
Purity
97.88% (May vary between batches)
Solubility
DMSO:8 mg/mL (16.1 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CCC (=O) Nc1cccc (Oc2nc (Nc3ccc (cc3OC) N3CCN (C) CC3) ncc2Cl) c1
Molecular Formula
C25H29ClN6O3
Molecular Weight
496.99
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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