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RAF265

RAF265 (CHIR-265) is a potent dual inhibitor targeting Raf kinases (C-Raf, B-Raf, B-Raf V600E) and VEGFR2, with IC50 values in the low nanomolar range. This compound has been investigated in Phase 2 clinical studies for oncology research, supporting its use in both in vitro biochemical assays and in vivo models of cancer and angiogenesis.

Product Specifications

CAS Number

927880-90-8

Product Name Alternative

Raf, Raf kinases, RAF 265, RAF265, RAF-265, VEGFR, VEGFR2, Vascular endothelial growth factor receptor, Inhibitor, inhibit, CHIR 265, CHIR265, CHIR-265, Autophagy, Apoptosis, B-Raf

Field of Research

Cardiovascular Research, Cell Biology, Signal Transduction

Purity

99.18% (May vary between batches)

Solubility

Ethanol:10.4 mg/mL (20.06 mM) ; DMSO:51.8 mg/mL (99.92 mM)

Smiles

Cn1c (Nc2ccc (cc2) C (F) (F) F) nc2cc (Oc3ccnc (c3) -c3ncc ([nH]3) C (F) (F) F) ccc12

Molecular Formula

C24H16F6N6O

Molecular Weight

518.41

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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