Tosedostat
Tosedostat (CHR-2797) is an orally active aminopeptidase inhibitor prodrug. Its intracellular metabolite, CHR-79888, targets M1 family enzymes like PuSA and LTA4 hydrolase, inducing amino acid deprivation and apoptosis in cancer cells. It has been investigated in preclinical and clinical studies for hematological malignancies and solid tumors.
Product Specifications
CAS Number
238750-77-1
Product Name Alternative
Aminopeptidase, CHR 2797, CHR2797, CHR-2797, Inhibitor, inhibit, M1-aminopeptidase, Tosedostat
Field of Research
Metabolism Research, Neuroscience
Purity
98.00% (May vary between batches)
Solubility
DMSO:55 mg/mL (135.31 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.92 mM)
Smiles
CC (C) C[C@H] ([C@H] (O) C (=O) NO) C (=O) N[C@H] (C (=O) OC1CCCC1) c1ccccc1
Molecular Formula
C21H30N2O6
Molecular Weight
406.47
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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