GDC-0879
GDC-0879 is a potent and selective small molecule inhibitor of B-Raf (IC50 = 0.13 nM) with additional activity against c-Raf. It is a valuable research tool for investigating MAPK/ERK pathway signaling in cancer biology, utilized in both in vitro cellular assays and in vivo xenograft models to study oncogenic BRAF-driven proliferation.
Product Specifications
CAS Number
905281-76-7
Product Name Alternative
Raf, Raf kinases, inhibit, Inhibitor, GDC0879, GDC-0879, GDC 0879, AR 00341677, AR00341677, AR-00341677, B-Raf
Field of Research
Signal Transduction
Purity
95.76% (May vary between batches)
Solubility
DMSO:150 mg/mL (448.6 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.98 mM)
Smiles
OCCn1cc (c (n1) -c1ccncc1) -c1ccc2\C (CCc2c1) =N\O
Molecular Formula
C19H18N4O2
Molecular Weight
334.37
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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