Desmethyl Erlotinib
Desmethyl Erlotinib (CP-473420) is the primary active metabolite of the EGFR inhibitor Erlotinib. It exhibits potent inhibitory activity against EGFR with an IC50 of 2 nM, making it a valuable reference compound for studying drug metabolism and efficacy in cancer research, both in vitro and in vivo.
Product Specifications
CAS Number
183321-86-0
Product Name Alternative
Desmethyl Erlotinib, DrugMetabolite, Drug Metabolite, CP 473420, CP 373420, CP473420, CP-473420, CP373420, CP-373420, EGFR, inhibit, Inhibitor, O-Desmethyl Erlotinib, OSI 420, OSI420, OSI-420
Field of Research
Cardiovascular Research, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
97.92% (May vary between batches)
Solubility
DMSO:83 mg/mL (218.76 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.7 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
COCCOc1cc2ncnc (Nc3cccc (c3) C#C) c2cc1OCCO
Molecular Formula
C21H21N3O4
Molecular Weight
379.41
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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