Allitinib tosylate
Allitinib tosylate (AST-1306) is a potent, irreversible small molecule inhibitor targeting EGFR and ErbB2, with respective IC50 values of 0.5 nM and 3 nM. It is utilized in cancer research for in vitro and in vivo studies, particularly in investigating resistance mechanisms in non-small cell lung and breast cancers.
Product Specifications
CAS Number
1050500-29-2
Product Name Alternative
HER2/ErbB2, FLT1, EGFR, EGFR (T790M/L858R), AST 1306, AST6, AST 6, AST1306, AST-1306 (TsOH), AST-1306 TsOH, anilino-quinazoline, TsOH
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.46% (May vary between batches)
Solubility
Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.44 mM) ; DMSO:114 mg/mL (183.55 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
Cc1ccc (cc1) S (O) (=O) =O.Fc1cccc (COc2ccc (Nc3ncnc4ccc (NC (=O) C=C) cc34) cc2Cl) c1
Molecular Formula
C31H26ClFN4O5S
Molecular Weight
621.08
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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