Tie2 kinase inhibitor 1
Tie2 kinase inhibitor 1 is a potent and selective small molecule derived from SB-203580, exhibiting a 200-fold greater potency for Tie2 (IC50 = 0.25 μM) over p38 MAP kinase. This inhibitor is a valuable research tool for investigating Tie2 receptor signaling in angiogenesis, with applications in both cellular and preclinical in vivo models of cancer and vascular biology.
Product Specifications
CAS Number
948557-43-5
Product Name Alternative
Endothelial, internal, kinase, Tie2 kinase inhibitor 1, Tie-2 kinase inhibitor 1, Tie2, Tie-2, tunica
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Purity
99.51% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.28 mM) ; DMSO:4.4 mg/mL (10.01 mM)
Smiles
COc1ccc2cc (ccc2c1) -c1[nH]c (nc1-c1ccncc1) -c1ccc (cc1) S (C) =O
Molecular Formula
C26H21N3O2S
Molecular Weight
439.53
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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