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Tie2 kinase inhibitor 1

Tie2 kinase inhibitor 1 is a potent and selective small molecule derived from SB-203580, exhibiting a 200-fold greater potency for Tie2 (IC50 = 0.25 μM) over p38 MAP kinase. This inhibitor is a valuable research tool for investigating Tie2 receptor signaling in angiogenesis, with applications in both cellular and preclinical in vivo models of cancer and vascular biology.

Product Specifications

CAS Number

948557-43-5

Product Name Alternative

Endothelial, internal, kinase, Tie2 kinase inhibitor 1, Tie-2 kinase inhibitor 1, Tie2, Tie-2, tunica

Field of Research

Pharmacology & Drug Discovery, Signal Transduction

Purity

99.51% (May vary between batches)

Solubility

H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.28 mM) ; DMSO:4.4 mg/mL (10.01 mM)

Smiles

COc1ccc2cc (ccc2c1) -c1[nH]c (nc1-c1ccncc1) -c1ccc (cc1) S (C) =O

Molecular Formula

C26H21N3O2S

Molecular Weight

439.53

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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