Amonafide
Amonafide is a topoisomerase II poison that induces protein-associated DNA strand breaks, but it does not inhibit topoisomerase I. This mechanism supports its investigation as an anticancer agent in both cellular and animal models for diseases like acute myeloid leukemia.
Product Specifications
CAS Number
69408-81-7
Product Name Alternative
Nafidimide, NSC308847, NSC308847, AS 1413, NSC308847, AS1413, NSC308847, AS-1413, AS-1413, AS1413, AS 1413, Amonafide, Topoisomerase, Topo II, Quinamed
Field of Research
Molecular Biology
Purity
98.00% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:4 mg/mL (14.12 mM) ; DMSO:53 mg/mL (187.06 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.06 mM)
Smiles
CN (C) CCN1C (=O) c2cccc3cc (N) cc (C1=O) c23
Molecular Formula
C16H17N3O2
Molecular Weight
283.33
Storage Conditions
-20°C
Notes
For research use only.
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