RepSox
RepSox is a potent and selective TGFβR-1/ALK5 inhibitor (IC50=23/4 nM) that blocks ATP binding and autophosphorylation. It is widely used in research to study TGF-β signaling, cellular differentiation like adipogenesis in MEFs, and in models of fibrosis and cancer.
Product Specifications
CAS Number
446859-33-2
Product Name Alternative
E-616452; SNJ 2511; 616452
Field of Research
Immunology & Inflammation, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
TGFβR-1 / ALK5 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml)
Smiles
Cc1cccc (n1) -c1n[nH]cc1-c1ccc2ncccc2n1
Molecular Formula
C17H13N5
Molecular Weight
287.3
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
2- (3- (6-Methylpyridine-2-yl) -1H-pyrazol-4-yl) -1,5-naphthyridine
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