NSC 23766 trihydrochloride
NSC 23766 trihydrochloride is a cell-permeable inhibitor that selectively blocks Rac1 GTPase activation by guanine nucleotide exchange factors (GEFs) with an IC50 of approximately 50 μM. It exhibits high specificity for Rac1 over the related Rho GTPases RhoA and Cdc42. This inhibitor is widely used in vitro to study Rac1-mediated cellular processes such as cytoskeletal reorganization, cell migration, and NADPH oxidase activation.
Product Specifications
CAS Number
1177865-17-6
Product Name Alternative
Rac GTPase, Ras, Apoptosis, NSC23766, NSC-23766, NSC23766 Trihydrochloride, NSC-23766 Trihydrochloride
Field of Research
Cell Biology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction
Purity
96.48% (May vary between batches)
Solubility
DMSO:53.1 mg/mL (100.01 mM) ; H2O:53.1 mg/mL (100.01 mM)
Smiles
Cl.Cl.Cl.CCN (CC) CCCC (C) Nc1nc (C) cc (Nc2ccc3nc (C) cc (N) c3c2) n1
Molecular Formula
C24H35N7·3HCl
Molecular Weight
530.96
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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