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NSC 23766 trihydrochloride

NSC 23766 trihydrochloride is a cell-permeable inhibitor that selectively blocks Rac1 GTPase activation by guanine nucleotide exchange factors (GEFs) with an IC50 of approximately 50 μM. It exhibits high specificity for Rac1 over the related Rho GTPases RhoA and Cdc42. This inhibitor is widely used in vitro to study Rac1-mediated cellular processes such as cytoskeletal reorganization, cell migration, and NADPH oxidase activation.

Product Specifications

CAS Number

1177865-17-6

Product Name Alternative

Rac GTPase, Ras, Apoptosis, NSC23766, NSC-23766, NSC23766 Trihydrochloride, NSC-23766 Trihydrochloride

Field of Research

Cell Biology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Purity

96.48% (May vary between batches)

Solubility

DMSO:53.1 mg/mL (100.01 mM) ; H2O:53.1 mg/mL (100.01 mM)

Smiles

Cl.Cl.Cl.CCN (CC) CCCC (C) Nc1nc (C) cc (Nc2ccc3nc (C) cc (N) c3c2) n1

Molecular Formula

C24H35N7·3HCl

Molecular Weight

530.96

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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