CHIR-124
CHIR-124 is a potent and selective inhibitor of Chk1 (IC50: 0.3 nM), exhibiting over 2,000-fold selectivity against Chk2 and minimal activity against Cdc2 and CDK2/4. This small molecule is a valuable research tool for studying DNA damage response pathways in both cellular and animal models of cancer.
Product Specifications
CAS Number
405168-58-3
Product Name Alternative
Cluster of differentiation antigen 135, CHIR 124, CHIR124, CHIR-124, Chk1, Checkpoint Kinase (Chk), CD135, Apoptosis, inhibit, Fms like tyrosine kinase 3, Fyn, FLT3, GSK3, GSK-3, Inhibitor, PDGFR, Platelet-derived growth factor receptor
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
96.33% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (1.19 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:15 mg/mL (35.72 mM)
Smiles
Clc1ccc2[nH]c (=O) c (-c3nc4ccccc4[nH]3) c (N[C@@H]3CN4CCC3CC4) c2c1
Molecular Formula
C23H22ClN5O
Molecular Weight
419.91
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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