(S) -crizotinib
(S) -Crizotinib (ent-crizotinib) is the (S) -enantiomer of crizotinib and acts as a potent MTH1 inhibitor with an IC50 of 72 nM. This small molecule is a valuable research tool for studying the role of MTH1 in DNA repair mechanisms, applicable in both in vitro and in vivo cancer research contexts.
Product Specifications
CAS Number
1374356-45-2
Product Name Alternative
DNASynthesis, DNA/RNA Synthesis, DNA Synthesis, crizotinib, anticancer, Apoptosis, (S) crizotinib, (S) crizotinib, (S) -Crizotinib, activity, mutT, inhibit, MTH1, nucleotide, homologue, Inhibitor, ent-crizotinib, RNA Synthesis, RNASynthesis, pool
Field of Research
Cell Biology, Molecular Biology, Pharmacology & Drug Discovery
Purity
98.52% (May vary between batches)
Solubility
1eq. HCl:9 mg/mL (19.98 mM) ; DMSO:22.5 mg/mL (49.96 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.22 mM)
Smiles
C[C@H] (Oc1cc (cnc1N) -c1cnn (c1) C1CCNCC1) c1c (Cl) ccc (F) c1Cl
Molecular Formula
C21H22Cl2FN5O
Molecular Weight
450.34
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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