ARQ 621
ARQ 621 is a selective, allosteric inhibitor of the mitotic kinesin Eg5 (KIF11) . It has been investigated in Phase 1 clinical studies for cancer and is used in preclinical research to study mitosis, aneuploidy, and tumor cell proliferation in both cellular and animal models.
Product Specifications
CAS Number
1095253-39-6
Product Name Alternative
Cell, division, Anti-tumor, ARQ 621, ARQ621, ARQ-621, microtubule, Kinesin, inhibit, motor, Inhibitor, Eg5 mitotic motor protein, Eg5, protein
Field of Research
Signal Transduction
Purity
97.01% (May vary between batches)
Solubility
Ethanol:93 mg/mL (168.35 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:93 mg/mL (168.35 mM)
Smiles
NCCCN ([C@H] (CC#C) c1nc2cc (Cl) ccc2c (=O) n1Nc1ccccc1) C (=O) c1cccc (Cl) c1F
Molecular Formula
C28H24Cl2FN5O2
Molecular Weight
552.43
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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