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Oritinib

Oritinib (SH-1028) is a potent and selective EGFR inhibitor, showing low nanomolar IC50 values against wild-type and various mutant forms, including the resistant T790M variant. It is a research tool for investigating targeted therapies in non-small cell lung cancer, with utility in both in vitro biochemical assays and in vivo preclinical models.

Product Specifications

CAS Number

2035089-28-0

Product Name Alternative

Inhibit, non-small cell lung cancer, Irreversible, mutant-selective, EGFR, EGFR (L858R), EGFR (L858R/T790M), EGFR (L861Q), EGFR (wt), EGFR TKI, EGFR-T790M, Epidermal growth factor receptor, ErbB-1, Inhibitor, HER1, Oritinib, third-generation, pharmacodynamics, SH1028, SH-1028, SH 1028

Field of Research

Cardiovascular Research, Signal Transduction

Purity

98.40% (May vary between batches)

Solubility

DMSO:120 mg/mL (222.36 mM)

Smiles

COc1cc (N (C) CCN (C) C) c (NC (=O) C=C) cc1Nc1nccc (n1) -c1c2CCCCn2c2ccccc12

Molecular Formula

C31H37N7O2

Molecular Weight

539.67

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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