MSC2504877
MSC2504877 is a tankyrase inhibitor that synergizes with clinical CDK4/6 inhibitors like palbociclib. It blocks the compensatory upregulation of Cyclin D2 and Cyclin E2 and augments phospho-Rb suppression, enhancing G1 cell cycle arrest in cancer research models, both in vitro and in vivo.
Product Specifications
CAS Number
1460286-21-8
Product Name Alternative
MSC 2504877, MSC2504877, MSC-2504877, 3- (4- (2-Hydroxypropan-2-yl) phenyl) -6-methylpyrrolo[1,2-a]pyrazin-1 (2H) -one, Tankyrase
Field of Research
Epigenetics & Chromatin, Molecular Biology
Purity
97.83% (May vary between batches)
Solubility
DMSO:3.6 mg/mL (12.75 mM)
Smiles
Cc1ccc2n1cc ([nH]c2=O) -c1ccc (cc1) C (C) (C) O
Molecular Formula
C17H18N2O2
Molecular Weight
282.34
Storage Conditions
-20°C
Notes
For research use only.
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