Idarubicin hydrochloride

Idarubicin hydrochloride, sold as Zavedos, is the hydrochloride salt form of the anthracycline Idarubicin. It functions as a DNA topoisomerase II inhibitor, exhibiting potent activity against MCF-7 breast cancer cells with an IC50 of 3.3 ng/mL. This compound is widely used in cancer research for in vitro cytotoxicity studies and in vivo models of leukemia and solid tumors.

Product Specifications

CAS Number

57852-57-0

Product Name Alternative

Topoisomerase, Topo II (MCF-7 cells), Zavedos, Bacterial, Antibiotic, Autophagy, 4-Demethoxydaunorubicin, 4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl, 4-Demethoxydaunorubicin hydrochloride, 4-Demethoxydaunorubicin Hydrochloride, c-Myc, breast tumor, DNA/RNA Synthesis, DNA synthesis, inhibit, Myc, Fungal, Idamycin, Idarubicin, Idarubicin HCl, Idarubicin Hydrochloride, Idarubicin hydrochloride, Inhibitor, leukaemias, MCF-7

Field of Research

Cell Biology, Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery

Purity

98.91% (May vary between batches)

Solubility

Ethanol:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:255 mg/mL (477.57 mM) ; H2O:5 mg/mL (9.36 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.18 mM)